GoFundMe Campaign

Numerous patients have found solace from a number of symptoms of their neurodegenerative or autoimmune diseases after the treatment with high dose thiamine. This is the main reason why our team has been relentlessly working every day since 2011 to provide patients worldwide with the opportunity to try our promising and safe therapy.

The healthunlocked.com forum, under the section dedicated to Parkinson’s Disease and the High Dose Thiamine protocol has become a phenomenal repository of patient’s feedback on the effectiveness of the therapy and the phenomenal impact that it has had on their lives.

“In April 2018, I stumbled upon HealthUnlocked and Dr. Constantini’s high dose vitamin B1 thiamine therapy. Thiamine has given me my life back, and as my husband says “it has given him his wife back”. Life for me is now about 94-95% of normal. Quite an improvement from a year prior to thiamine therapy, where my world had become small and limited. Now I do everything and go everywhere.”

There are countless feedback like the one above.

However, there is also widespread skepticism, as it is understandable, surrounding a novel therapy like the one discussed on this website, so effective yet so simple. When hundred of millions USD are spent for the research, the high dose thiamine therapy might show the light at the end of the tunnel, though for those who are lacking the first person experience it is easy to assume that such light is an hallucination.

To this end, a multi-location randominzed double-blind placebo-controlled trial covering a representative number of patients and spanning over the relevant time frame is necessary for informing scientifically and with statistical significance on the effectiveness of the therapy, understand and describe its mechanisms and potentially further improve its efficacy and thus obtain the authorization to become a standard therapy.

This type of research requires an authorized structure and a relevant budget for its execution. Over the past months our team has been able to establish contacts with an Italian public hospital, a recognized clinic in the UK and a number of health research centers in the United States that could perform the study, provided that funds are available.

In order to collect the minimum amount of funds necessary for carrying out this complex multi-location trial, we have started a GoFundMe campaign to support this endeavor with the goal to raise the necessary amount to mainstream the High Dose Thiamine therapy and make it accessible, through your own informed practitioner, everywhere in the world.

Consider donating to this research:



Voice of the Patients (and their family members)

The video interview below reports the story of another patient affected by Parkinson’s Disease and his wife. The patient was diagnosed with PD in 2007 and until 2014 his general condition has worsened to the point that the patient had an accident and was hospitalized. The doctors who examined the patient in 2014 assessed that the condition of the patient was particularly severe and communicated to his wife that she should prepare for the worst to happen soon.

This patient’s wife did not give up and looked for further support until she was told to try the high dose thiamine therapy. He husband, filmed in this interview before the treatment, had severe symptoms of PD including difficulties in maintaining focus, difficult speech, inability to stand and even sit (needed straps to hold him in place while on a wheel chair). The improvements after the high-dose thiamine protocol are evident and are sustained today, in October 2018, almost 4 and a half years after the beginning of the therapy.

In this remarkable case, not only the patient has seen the development of the disease disappear (against the sentence announced by the responsible hospital MD who treated him in 2014 and announced his death as imminent) but the regression of most of the symptoms and the regaining of a normal life has been startling.

In this video interview the patient explains his story and serves as a perfect example to show the potential of this novel therapy.

Voice of the Patients

In this section of the website we include the feedback of some of our patients because they are the main stakeholders in this endeavour.

Video Interview of a patient affected by Parkinson’s Disease:



In this section users can find the list of published articles on the use of high dose thiamine.

Articles should not be downloaded and used for any purpose without the written agreement of the editor.

High-dose thiamine improves the symptoms
of fibromyalgia

High-dose thiamine and essential tremor

Thiamine and spinocerebellar ataxia type 2

Thiamine and Fatigue in Inflammatory Bowel Diseases:
An Open-label Pilot Study

Thiamine and Hashimoto’s Thyroiditis:
A Report of Three Cases

High-Dose Thiamine Improves Fatigue After Stroke:
A Report of Three Cases

High-dose thiamine as initial treatment
for Parkinson’s disease

An open-label pilot study with
high-dose thiamine in Parkinson’s

High dose thiamine improves fatigue
in multiple sclerosis

Long-term treatment with thiamine as possible medical therapy
for Friedreich ataxia

High-dose thiamine improves the symptoms
of Friedreich’s ataxia

Oral High-Dose Thiamine Improves the Symptoms of
Chronic Cluster Headache

Thiamine Therapy for Dystonia Type 1

Long-Term Treatment with High-Dose
Thiamine in Parkinson Disease:
An Open-Label Pilot Study